Pyridinyl-quinolone compounds, their preparation and use

Details Pyridinyl-quinolone compounds, their preparation and use Pyridinyl-quinolone compounds, their preparation and use

1989-09-13

1991-12-24

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 4, 546156, 560 35, 560 38, 560 51, A61K 3147, C07D40104

Patent

active

050753193

ABSTRACT:
Fluorinated 1-cyclopropyl-7-(substituted-pyridinyl)-1,4-dihydro-4-oxo-3-quinolinecarbo xylic acids of the formula ##STR1## wherein R is hydrogen, R' and R" are hydrogen or fluoro, or other groups and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They are prepared via a coupling reaction between the corresponding esters (R=alkyl) having a halo group in the 7-position and a substituted (trialkylstannyl)pyridine.

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Wise et al, Antimicrobial Agents and Chemotherapy, 23, pp. 559-564 (1983).

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