Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-02-11
1993-08-17
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514349, 514350, 514352, 514354, 546276, 546297, 546310, 546312, 546304, 546256, 544315, 544319, 544333, C07D40112, A61K 3144
Patent
active
052369374
ABSTRACT:
The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Rz, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment. ##STR1##
REFERENCES:
patent: 4820843 (1989-04-01), Aldrich et al.
patent: 4880804 (1989-11-01), Carini et al.
A. D. Shevchenko, et al., "Synthesis of some p-(aminomethyl)benzoic acid derivatives and their properties" Chem. Abstr. (1977), 86, 171.350u.
G. R. Proctor, et al., "Azabenzocycloheptenones. Part XIV. Cyclisation of Amino-acid Derivatives to Tetrahydro-1-benzazepin-5-ones and Tetrahydroquiolin-4-ones" J. Chem. Soc., Perkin Trans. I (1972), 1803-1808.
Bradbury Robert H.
Edwards Martin P.
Ratcliffe Arnold H.
Davis Zinna N.
Imperial Chemical Industries plc
Ivy C. Warren
Jackson Thomas E.
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