Pyridinyl acetamide compounds useful in treating ulcers

Details Pyridinyl acetamide compounds useful in treating ulcers Pyridinyl acetamide compounds useful in treating ulcers

1989-08-16

1990-08-21

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142355, 514252, 514318, 514352, 514341, 514342, 514343, 544 60, 544124, 544360, 546194, 546276, 546280, 546281, 546309, A61K 3144

Patent

active

049506676

ABSTRACT:
There are provided acetamide compounds represented by the following formula; ##STR1## wherein R.sub.1 and R.sub.2 each independently represents a hydrogen atom, a C.sub.1 to C.sub.6 straight- or branched-chain alkyl or alkenyl group, a C.sub.3 to C.sub.6 cycloalkyl or cycloalkenyl group, or a C.sub.6 to C.sub.10 aromatic group; or R.sub.1 and R.sub.2 combine with each other in combination with the adjacent N and carbon atoms or further with at least one of nitrogen, oxygen and sulfur atoms to represent a 5- to 6-membered heterocyclic ring group; R.sub.3 represents hydrogen atom, a C.sub.1 to C.sub.6 straight- or branched-chain alkyl or alkenyl group, a C.sub.3 to C.sub.6 cycloalkyl or cycloalkenyl group, a halogen atom, a C.sub.1 to C.sub.6 straight- or branched-chain alkyloxy group, or a C.sub.3 to C.sub.6 cycloalkyloxy or cycloalkenyloxy group; and n is an integer of 1 to 4, and their pharmaceutically acceptable salts.
The compounds and the salts exhibit potent anti-ulcer activity and are useful for treating ulcer in mammals.

REFERENCES:
patent: 4297357 (1981-10-01), Miki et al.

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