Pyridinoylpiperidines as 5-HT 1F agonists

Details Pyridinoylpiperidines as 5-HT 1F agonists Pyridinoylpiperidines as 5-HT 1F agonists

2008-07-22

2011-10-25

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08044207

ABSTRACT:
The invention relates to compounds of formula I:or pharmaceutically acceptable acid addition salts thereof, where; R1is C1-C6alkyl, substituted C1-C6alkyl, C3-C7cycloalkyl, substituted C3-C7cycloalkyl, C3-C7cycloalkyl-C1-C3alkyl, substituted C3-C7cycloalkyl-C1-C3alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle;R2is hydrogen, C1-C3alkyl, C3-C6cycloalkyl-C1-C3alkyl, or a group of formula II;R3is hydrogen or C1-C3alkyl;R4is hydrogen, halo, or C1-C3alkyl;R5is hydrogen or C1-C3alkyl;R6is hydrogen or C1-C6alkyl; andn is an integer from 1 to 6 inclusively.The compounds of the present invention are useful for activating 5-HT1Freceptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

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