Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-01-11
2005-01-11
Dentz, Bernard (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S080000, C514S081000, C514S224200, C514S230500, C514S299000, C514S302000, C514S306000, C544S047000, C544S090000, C546S023000, C546S114000, C546S116000, C546S138000, C546S183000
Reexamination Certificate
active
06841559
ABSTRACT:
Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselective and functional group tolerant methods for the synthesis of the novel pyridinones are also provided. One such synthetic method involves reacting an imine and a Meldrum's acid derivative in solution. The other synthetic method is a solid phase synthesis of the pyridinones in which an imine is prepared bound to a solid support and a Meldrum's acid derivative is reacted with the imine. Novel imine intermediates useful in the solid phase and solution methods of synthesizing the pyridionones are also described.
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Supplementary Partial European Search Report from EP 00 98 2170 dtd Jan. 27, 2003.
Almqvist Frederic
Emtenas Hans
Hultgren Scott J.
Pinkner Jerome S.
Dentz Bernard
Senniger Powers
Washington University of St. Louis
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