Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-31
1998-04-28
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546194, 546208, A61K 31445, C07D21106
Patent
active
057444862
ABSTRACT:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and have the following structure: ##STR1## for example: ##STR2##
REFERENCES:
patent: 5260307 (1993-11-01), Ackermann et al.
patent: 5405854 (1995-04-01), Ackermann et al.
Bernstein, et al., J. Med. Chem., 37, 3313-3326 "Nonpeptidic Inhibitors of Human Leukocyte Elastase . . . ", 1994.
Dorsey Bruce D.
Dyer Dona L.
Fraley Mark E.
Isaacs Richard C. A.
Naylor-Olsen Adel M.
Aulakh Charanjit S.
Ivy C. Warren
Merck & Co. , Inc.
Parr Richard S.
Winokur Melvin
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