Pyridinium compounds

Details Pyridinium compounds Pyridinium compounds

1994-02-08

1998-02-03

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546292, 546303, 546338, 514345, 514346, C07D21375, C07D21377, C07D21353, C07D21346

Patent

active

057146152

ABSTRACT:
Methods for using novel quaternary pyridinium compounds in inhibiting acetylcholinesterase in mammals, specifically using the quaternary pyridinium compounds in the prophylaxis and treatment of organophosphate poisoning and mammalian dementia by mimicking or opposing the actions of the natural neurotransmitter acetylcholine.

REFERENCES:
patent: 5180831 (1993-01-01), Powers et al.
patent: 5206371 (1993-04-01), Powers et al.
Buccafusco, J. J., et al., J. Pharmacol. Exp. Ther., 1986, 239, 43.
Buccafusco, J. J., et al., Neurobiol. Aging 12: 233-238 (1991).
Terry, A. V., et al., Pharmacol. Biochem. Behav. 45: 925-929 (1993).

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