Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-07-01
2008-11-25
Davis, Zinna N (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S255000, C546S268100, C546S347000, C435S455000, C514S317000, C514S358000
Reexamination Certificate
active
07456197
ABSTRACT:
Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents.
REFERENCES:
patent: 6020202 (2000-02-01), Jessee
Abstract: Symposium of Structural Biology 2002; poster; “Heterocyclic Cationic Lipids As Gene Transfer Agents”; Alexandru T. Balaban, Marc Antoniu Ilies, William A. Seitz, Melissa Wentz, and Robert E. Garfield; 2002.
Poster Content: Biophex/Interphex 2002; “Heterocyclic Cationic Lipids As Gene Transfer Agents”; Alexandru T. Balaban, Marc Antoniu Ilies, William A. Seitz, Melissa Wentz, and Robert E. Garfield; 2002.
Poster Content: Biophex/Interphex 2002; “Evaluation of lipoplex delivery systems for gene therapy”; Fred O. Makori, Betty H. Johnson, Aaron Miller, Alexandru T. Balaban, Marc A. Ilies, and E. Brad Thompson; 2002.
Abstract: 225thAmerican Chemical Society (ACS) National Meeting (lecture in the Division of Medicinal Chemistry kept by Professor A.T. Balaban); “Heterocyclic Cationic Lipids As Gene Transfer Agents”; A.T. Balaban, M.A. Ilies, W.A. Seitz, M. Wentz, and R.E. Garfield; 2003.
Presentation Content: 225thAmerican Chemical Society (ACS) National Meeting; lecture in the Division of Medicinal Chemistry by Professor A.T. Balaban; “Heterocyclic Cationic Lipids As Gene Transfer Agents”; A.T. Balaban, M.A. Ilies, W.A. Seitz, M. Wentz, and R.E. Garfield; 2003.
Abstract: 227thACS National Meeting; lecture in the Division of Colloid and Surface Chemistry by Dr. M.A. Ilies; “Lipophilic pyrylium salts in the synthesis of pyridinium-based cationic lipids and gemini surfactants for gene transfer”; M.A. Ilies, W.A. Seitz, B.H. Johnson, A. Miller, E.B. Thompson, A.T. Balaban; 2004.
Presentation Content: 227thACS National Meeting; lecture in the Division of Colloid and Surface Chemistry by Dr. M.A. Ilies; “Lipophilic pyrylium salts in the synthesis of pyridinium-based cationic lipids and gemini surfactants for gene transfer”; M.A. Ilies, W.A. Seitz, B.H. Johnson, A. Miller, E.B. Thompson, A.T. Balaban; 2004.
Poster Abstract: 227thACS National Meeting; “Structure-activity relationships in a seriesof pyridinium-based cationic lipids”; Marc Antoniu Ilies, William A. Seitz, Betty H. Johnson, Aaron Miller, E. Brad Thompson, and Alexandru T. Balaban; 2004.
Poster Content: 227thACS National Meeting; “Structure-activity relationships in a seriesof pyridinium-based cationic lipids”; Marc Antoniu Ilies, William A. Seitz, Betty H. Johnson, Aaron Miller, E. Brad Thompson, and Alexandru T. Balaban; 2004.
Poster Abstract: American Society of Gene Therapy's 7thAnnual Meeting: “New pyridinium cationic lipids for gene delivery synthesized via pyrylium salts”; Marc Antoniu Ilies, Betty H. Johnson, William A. Seitz, Ed L. Ezell, Aaron Miller, E. Brad Thompson, and Alexandru T. Balaban; 2004.
Poster Content: American Society of Gene Therapy's 7thAnnual Meeting: “New pyridinium cationic lipids for gene delivery synthesized via pyrylium salts”; Marc Antoniu Ilies, Betty H. Johnson, William A. Seitz, Ed L. Ezell, Aaron Miller, E. Brad Thompson, and Alexandru T. Balaban; 2004.
Marc Antoniu Ilies, William A. Seitz, Miron T. Caproiu, Melissa Wentz, Robert E. Garfield and Alexandru T. Balaban; “Pyridinium-Based Cationic Lipids as Gene-Transfer Agents”; Eur. J. Org. Chem. 2003, 2645-2655.
Marc Antoniu Ilies, William A. Seitz, Ion Ghiviriga, Betty H. Johnson, Aaron Miller, E. Brad Thompson and Alexandru T. Balaban; “Pyridinium Cationic Lipids in Gene Delivery: A Structure—Activity Correlation Study”; American Chemical Society, Journal of Medicinal Chemistry; Jan. 6, 2004 (Published on Internet); 11 pgs.
Marc Antoniu Ilies & Alexandru T. Balaban; “Recent developments in cationic lipid-mediated gene delivery and gene therapy”; Ashley Publications, 2001; 1729-1752.
Marc Antoniu Ilies, William A. Seitz and Alexandru T. Balaban; “Cationic Lipids in Gene Delivery: Principles, Vector Design and Therapeutical Applications”; Current Pharmaceutical Design, Dec. 2002; 2441-2473.
Balaban Alexandru T.
Garfield Robert E.
Ilies Marc A. C.
Johnson Betty H.
Miller Aaron L.
Davis Zinna N
Howrey LLP
The Texas A&M University System
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