Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-08-19
1993-10-05
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514252, 540575, 544365, 546316, 546323, C07D40104, C07D40106, A61K 31495, A61K 3155
Patent
active
052505260
ABSTRACT:
Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.3 alkyl or diphenylmethyl; Y is --NH(CH.sub.2).sub.n --R.sub.2 ; R.sub.2 is OH or --ONO.sub.2 ; m is 2 or 3; and n is 9 to 13 or physiologically acceptable acid addition salts thereof. The compounds of formula (I) are of a blood flow-increasing and hypotensive actions and can be used for the therapy or prevention of diseases in the cardiovascular system.
REFERENCES:
patent: 4200640 (1980-04-01), Nagano et al.
patent: 4780560 (1988-10-01), Kumonaka et al.
patent: 4994456 (1991-02-01), Miura et al.
patent: 5025012 (1991-06-01), Miura et al.
Organic Synthesis, Collective vol. 3, E. C. Horning, ed., pp. 723-725, Roland Icke, et al., ".beta.-Phenylethyldimethylamine" (1955).
Horigome Masato
Koyama Hiroyasu
Miura Katsutoshi
Sakurai Einosuke
Sugai Toshiji
Bernhardt Emily
Nisshin Flour Milling Co. Ltd.
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