Pyridine soluble extract of a microorganism

Details Pyridine soluble extract of a microorganism Pyridine soluble extract of a microorganism

1984-04-17

1985-03-12

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A61K 3578

Patent

active

045044732

ABSTRACT:
A pharmaceutical composition is disclosed comprising a purified pyridine-soluble extract obtained from microorganism which contains between about 7 and 20% by weight of protein, between about 10 and 16% by weight of sugar, and between about 35 and 55% by weight of fatty acids which when combined with trehalose dimycolate and an acetone precipitated by-product of endotoxic glycol lipids extracted with chloroform-methanol in a pharmaceutically acceptable medium is useful as an anti-animal tumor agent in the treatment of animals.

REFERENCES:
patent: 3956481 (1976-05-01), Jolles et al.
patent: 3976544 (1976-08-01), Adam et al.
Meyer et al., J. Natl. Can. Inst. 52: 103-108, 1974.
Ribi et al., Natl. Can. Inst., Monograph, No. 39, 1974.
Rozencweig et al., Canc., 40: 334-342, 1977.
Pharmacological Basis of Cancer Chem., Williams & Wilkins Co., 1975, pp. 245-270.

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