Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-21
2008-03-25
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07348432
ABSTRACT:
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
REFERENCES:
patent: 5618819 (1997-04-01), Guillaumet et al.
patent: 5811432 (1998-09-01), Marfat et al.
patent: 6635652 (2003-10-01), Kawashima et al.
patent: 1219621 (2002-07-01), None
patent: 1357124 (2003-10-01), None
patent: 01161239 (1989-06-01), None
patent: 02281203 (1990-11-01), None
patent: 1219621 (2002-03-01), None
patent: WO 00/53178 (2000-09-01), None
patent: WO 00/69859 (2000-11-01), None
patent: WO 01/49288 (2001-07-01), None
patent: WO 03/082868 (2003-10-01), None
patent: WO 03/082869 (2003-10-01), None
patent: WO 2004/082586 (2004-09-01), None
Gudumndsson et al. Synthetic Communications, 1997, 27(10), 1763-1775.
Yamanaka, et al. Chemical & Pharmaceutical Bulletin, 1992, 40(3), 666-674.
Enguehard et al.: J. Org. Chem., vol. 68, No. 11, 2003, pp. 4368-4370.
Enguehard, C. et al.: “Ipso-orCine-Substitutions of 6-Haloimidazo[1,2-a]pyridine Derivatives with Different Azoles Depending on the Reaction Conditions”, J. Org. Chem. 2003, 68, pp. 5614-5617.
Viaud, Marie-Claude et al.: “Acylation of Oxazolo[4,5-b]Pyridin-2(3H)-Ones, 2-Phenyloxazolo[4,5-b]Pyridines and Pyrrolo[2,3-b]Pyridin-2(2H)-Ones”; Tetrahedron, vol. 53, No. 14, 1997, pp. 5159-5168.
Berman, J.M. et al ‘Compositions Comprising Multiple Antibiotic Agents Including a Fabl Inhibitor, Methods of Using the Same, and Preparation of the Heterocycle Fabl Inhibitors’ Chemical Abstracts Service, XP-002371268. Database Accession No. 2004:799437. Abstract. (WO 04/082586).
Dolzhenko, A.V. et al Synthesis and Structural Studies of (2-OXO-2,3-dihydroimidazo[1,2-a]pyridin-3-YL) Acetic Acids Chemical Abstracts Service, XP-002371263. Database Accession No. 2004:14830. Heterocycles, 63(1), 55-62, (2004). Abstract & Article.
Gudmundsson, K.S. et al ‘An Improved Synthesis of 2-Chlorinated Imidazo[1,2-a]pyridines and the Application of this Procedure for the Synthesis of Several New Polychlorinated Imadazo[1,2-a]pyridines’ Chemical Abstracts Service, XP-002371264. Database Accession No. 1997:323396. Synthetic Communications, 27(10), 1763-1775, (1997). Abstract & Article.
Komamura, T, et al ‘Color Photothermographic Material’ Chemical Abstracts Service, XP-002371267. Database Accession No. 1990:129196. Abstract (JP01161239).
La Manna, A. et al. ‘Synthesis of 5-Substituted 7-azaoxindoles’ Chemical Abstracts Service, XP-002371270. Database Accession No. 1973:478649. Bollettino Chimico Farmaceutico, 112(1), 22-8, (1973). Abstract & Article.
Marfat, A., et al ‘Preparation of Azaoxindole-1-carboxamides as Antiinflammatories and Analgesics’ Chemical Abstracts Service, XP-002371269. Database Accession No. 1998:618366. (US 5,811,432).
Marshall, R.L. ‘Product Subclass 27: Benzylstannanes’ Chemical Abstracts Service, XP-002371273. Database Accession No. 2003:158796. Science of Synthesis, 5, 559-571, (2003). Abstract & Article.
Mochizuki, Y., et al ‘Color Filter for Liquid Crystal Display’ Chemical Abstracts Service, XP-002371266. Database Accession No. 1991:256740. Abstract. (JP02281203).
Viaud, M.C. et al ‘Pyrrolo[2,3-b]pyridin-2(2H)-One Derivatives as Potential Non-Opioid Analgesic Agents’ Chemical Abstracts Service, XP-002371308. Database Accession No. 1997:573435. Pharmaceutical Sciences, 3(5/6), 283-287 (1997). Abstract & Article.
Yamanaka, M. et al ‘Imidazo[1,2-a]pyridines.II. Ozonolysis of Imidazo[1,2-a]pyridines and Synthesis of Cardiotonic Agents’ Chemical Abstracts Service. XP-002371265. Chemical & Pharmaceutical Bulletin, 40(3), 666-74 (1992). Abstract & Article.
PCT International Search Report re: PCT/US2005/037820 dated Mar. 24, 2006.
Fiordeliso James J.
Jiang Weiqin
Sui Zhihua
Chandrakumar Nizal S.
Janssen Phamaceutica N.V.
Seaman D. Margaret
LandOfFree
Pyridine imidazoles and aza-indoles as progesterone receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyridine imidazoles and aza-indoles as progesterone receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridine imidazoles and aza-indoles as progesterone receptor... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3975638