Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-03-27
2008-12-23
Seaman, D. Margaret (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S352000, C546S292000, C546S304000
Reexamination Certificate
active
07468382
ABSTRACT:
Disclosed are novel compounds of formula (I):wherein R1, R2and R3are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
REFERENCES:
patent: 3929785 (1975-12-01), Ramanathan
patent: 2004/0242613 (2004-12-01), Cardozo
patent: WO 03/106451 (2003-12-01), None
Marsland et al., J. Exp. Med., 2004, vol. 200, pp. 181-189.
Brunette Steven Richard
Kim Jin Mi
Lemieux Rene′ Marc
Tschantz Matt Aaron
Boehringer Ingelheim International GmbH
Datlow Philip I.
Devlin Mary-Ellen M.
Morris Michael P.
Rahmani Niloofar
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