Pyridine derivatives

Details Pyridine derivatives Pyridine derivatives

1989-10-20

1991-10-01

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514333, 514278, 546268, 546256, 546283, 546284, 546 15, C07D45106, A61K 3146

Patent

active

050534157

ABSTRACT:
The invention concerns novel, pharmaceutically useful 1,3-dioxane alkenoic acid derivatives of the formula I containing a pyridyl moiety at position 4 of the dioxane ring and in which the groups at positions 2, 4 and 5 have cis-relative stereochemistry, X is hydrogen, alkoxy or hydroxy, Y is vinylene, n is 1 or 2, A.sup.1 is alkylene, the substituents R.sup.1 and R.sup.2 at position 2 of the dioxane ring have a variety of values defined hereinafter, and R.sup.4 is hydroxy, a physiologically acceptable alcohol residue or alkanesulphonamido, and the pharmaceutically acceptable salts thereof. The invention also includes processes for the manufacture and use of the acid derivatives as well as pharmaceutical compositions for therapeutic use in one or more of a variety of diseases such as ischaemic heart disease, cerebrovascular disease, asthmatic disease and/or inflammatory disease.

REFERENCES:
patent: 4554011 (1985-11-01), Loh
patent: 4567197 (1986-01-01), Brewster
patent: 4735963 (1988-04-01), Matassa
patent: 4736057 (1988-04-01), Guildford
patent: 4755684 (1988-10-01), Smithers
patent: 4831046 (1989-05-01), Brown
patent: 4921866 (1990-05-01), Brewster et al.

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