Pyridine derivatives

Details Pyridine derivatives Pyridine derivatives

1997-12-04

1999-10-12

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

5142352, 514253, 514308, 544235, 544237, 544284, 546122, 546140, 546141, 546144, 546147, 546167, A61K 3147, A61K 31535, C07D40114, C07D41314

Patent

active

059657308

ABSTRACT:
A pyridine derivative of the formula (I): ##STR1## wherein A is group of the following formulae: ##STR2## (R.sup.1 and R.sup.2 are each H, or protected or unprotected OH, R.sup.31, R.sup.41 and R.sup.42 are protected or unprotected hydroxymethyl, R.sup.32 is H, lower alkyl, or protected or unprotected hydroxymethyl, R.sup.33 is substituted or unsubstituted lower alkyl, and the dotted line means the presence or absence of a double bond), R.sup.5 and R.sup.6 are H, or protected or unprotected amino, or both combine together with the adjacent nitrogen to form substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof, these compounds showing excellent bronchoconstriction inhibitory activity and/or anti-inflammatory activity of airway, and being useful in the prophylaxis or treatment of asthma.

REFERENCES:
patent: 5177085 (1993-01-01), Naef
patent: 5342941 (1994-08-01), Iwasaki et al.

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