Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-04-06
1991-12-24
Scalzo, Catherine S. Kilby
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514312, 514313, 514314, 514311, 540597, 546 16, 546 21, 546 23, 546153, 546155, 546157, 546159, 546171, 546175, 546176, 546177, 546179, 546180, C07D40104, C07D51304, A61K 3147
Patent
active
050753037
ABSTRACT:
Pyridine derivatives of formula ##STR1## their heteroaromatic N-oxides and their pharmaceutically acceptable acid addition salts are disclosed. In the formula z is 0, 1 and 2 and R, R.sup.1, R.sup.2 and R.sup.2 have specified meanings. The compounds exhibit activity as 5-HT.sub.1A agonists, antagonists or partial agonists and are useful for the treatment of CNS disorders e.g. anxiety, as antihypertensives and in treating anorexia.
REFERENCES:
patent: 4878941 (1989-11-01), Theodoridis
patent: 4894084 (1990-01-01), Theodoridis
Ornstein et al., "Molecular Models", Chem-Biol. Interactions, 30 (1980), 87-103.
Cliffe Ian A.
Mansell Howard L.
Todd Richard S.
White Alan C.
John Wyeth & Brother Limited
Kilby Scalzo Catherine S.
Tarnowski George
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