Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-01-29
2011-12-20
Kosar, Andrew D (Department: 1622)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S235500, C544S124000
Reexamination Certificate
active
08080543
ABSTRACT:
The present invention relates to pyridine substituted ethanol compounds and derivatives thereof having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
REFERENCES:
patent: 6706720 (2004-03-01), Atwal et al.
patent: 2006/014877 (2006-02-01), None
patent: 2006/015159 (2006-02-01), None
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Kokosa, J. M., “Dehydrative Metabolites of 1-(3-Chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine)ethanol as Potential Hypocholesteremic Agents”, Journal of Medicinal Chemistry, vol. 21, No. 2,pp. 225-228 (1978).
Decher, Niels et al., “Molecular Basis for Kv1.5 Channel Block”, The Journal of Biological Chemistry, vol. 279, No. 1, pp. 394-400 (2004).
Armando Lagrutta et al., “Novel, Potent Inhibitors of Human Kv1.5 K+ Channels and Ultrarapidly Activating Delayed Rectifier Potassium Current”, The Journal of Pharmacology and Experimental Therapeutics, vol. 317, No. 3.; accepted Mar. 3, 2006. pp. 1054-1063.
Michael F. Gross et al., “Aryl Sulfonamido Indane Inhibitors of the Kv1.5 Ion Channel”, Elsevier, ScienceDirect, Bioorganic & Medicinal Chemistry Letters 17, accepted Feb. 27, 2007 pp. 2849-2853.
Kett Nathan R.
Nanda Kausik K.
Trotter B. Wesley
Daniel Mark R.
Kosar Andrew D
Merck Sharp & Dohme
Parr Richard S.
Rodriguez-Garcia Valerie
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