Pyridine compound and pharmaceutical compostions

Details Pyridine compound and pharmaceutical compostions Pyridine compound and pharmaceutical compostions

1994-12-01

1996-04-02

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514218, 5142282, 5142285, 5142338, 5142342, 514253, 514303, 514307, 514314, 514318, 514338, 540575, 544 584, 544 62, 544124, 544131, 544360, 546118, 546148, 546165, 546199, 546270, 546271, A61K 3144, A61K 31535, C07D40112, C07D41314

Patent

active

055040829

ABSTRACT:
A pyridine compound of the formula ##STR1## wherein R.sup.1 is a hydrogen, a halogen, an alkyl, an alkoxy or the like, R.sup.2 and R.sup.3 are each a hydrogen, a halogen or an alkyl, --P.dbd.Q-- is --CH.dbd.CH--, --N.dbd.CH-- or --CH.dbd.N--, A is an oxygen atom, a sulfur atom or N(R.sup.4) wherein R.sup.4 is hydrogen, alkyl or the like, n is 0, 1 or 2, B is S(O)p wherein p is 0, 1 or 2, D is a single bond, an alkylene or the like and E is an alkoxyalkyl or --N(R.sup.6)(R.sup.7), and a pharmaceutically acceptable salt thereof have antibacterial activity against Helicobater pylori, antiulcer activity, gastrointestinal cytoprotective activity, ulcer recurrence, relapse-preventive activity and gastric acid secretion-suppressive activity and are useful as pharmaceutical preparations.

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Suerbraum et al., Eur. J. Clin. Microbiol. Infect. Dis., 10(2), 92-93 (1991).
Derwent Publications, Ltd., Abstract No. B0186 (1994) (abstract of JP 06100449-A).
Derwent Publications, Ltd., Abstract No. B0200 (1991) (abstract of JO 3038523A).
Derwent Publications, Ltd., Abstract No. B0205 (1991) (abstract of JO 3048680A).
Derwent Publications, Ltd., Abstract No. B0143 (1991) (abstract of JO 3052887A).
Derwent Publications, Ltd., Abstract No. B0125 (1991) (abstract of JO 3052812A).

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