Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to lymphokine – cytokine – or other secreted growth...
Patent
1995-01-19
1998-01-13
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to lymphokine, cytokine, or other secreted growth...
424 153, 424 157, 424 165, 424 169, 424 173, 534 10, 534 14, 5303915, 5303917, 546256, 546257, A61K 5104, C07F 1300, C07D21322
Patent
active
057076030
ABSTRACT:
The invention provides targeting radioactive immunoreagents comprising a metal radionuclide ion, a complexing agent having structure A-I, as defined in the specification, and an immunoreactive group covalently bonded to the complexing agent. The present invention also provides novel complexing agents having the structure A-I, as defined in the specification. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.
REFERENCES:
patent: 4637988 (1987-01-01), Hinshaw et al.
patent: 4670572 (1987-06-01), Hinshaw et al.
patent: 4745076 (1988-05-01), Muller et al.
patent: 4761481 (1988-08-01), Hale et al.
patent: 4767611 (1988-08-01), Gordon
patent: 4794191 (1988-12-01), Hinshaw et al.
patent: 4801722 (1989-01-01), Hinshaw et al.
patent: 4837169 (1989-06-01), Toner
patent: 4859777 (1989-08-01), Toner
patent: 4960895 (1990-10-01), Ohkara
patent: 5075447 (1991-12-01), Muller et al.
patent: 5202423 (1993-04-01), Kankare et al.
patent: 5204448 (1993-04-01), Subramanian
Brechbiol et al. "Synthesis of 1-(p-Isothio cyanatobenzyl) Derivatives of DTPA & EDTA". . . Inorg. Chem. 25, 2772-81 (1986).
Chandler et al. (1981) J. Heterocyclic Chem. 18: 599-601.
S.E. Order et al, "Use of Isotropic Immunoglobulin in Therapy" Cancer Research 40, 3001-7 (Aug. 1980).
Scheinberg et al, "Tumor Imaging with Radioactive Metal Chelates Conjugated to Monoclonal Antibodies", Science 215, No. 19, 1511-13 (Mar. 1982).
Khan et al, "Myocardial Infarct Imaging of Antibodies to Canine Cardiac Myosin with Indium-111-Diethylenetriamine Pentaacetic Acid", Science 209, 295-7 (Jul. 1980).
Brechbiel et al, "Synthesis of 1-(p-Isothicyanatobanzyl) Derivities of DTPA and EDTA Antibody Labeling and Tumor Imaging Studies", Inorg. Chem 25, 2772-81 (1986).
Parker et al, "Implementation of Macrocycle Conjugated Antibodies for Tumor Targeting", Pure and Applied Chem. 61, No. 9, 1637-41 (1989).
Cox et al, "Synthesis of a Kinetically Stable Yttrium-90 Labelled Macrocycle-Antibody Conjugate", J. Chem. Soc., Chem. Commun. 797-8 (1989).
Craig et al, "Towards Tumor Imaging with Indium-III Labelled Macrocycle-Antibody Conjugates" J. Chem. Soc. Chem. Comm., 794-6 (1989).
Mather et al, "Labelling Monoclonal Antibodies with Yttrium 90", Eur. J. Nucl. Med. 15, 307-12 (1989).
Hilborn David A.
Hossain Timothy Z.
Murray Bruce J.
Philion Richard
Saha Ashis K.
Kelley Lara C.
Kight John
Nycomed Imaging AS
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