Pyridine carboxylic acid amides for mycobacterium infections

Details Pyridine carboxylic acid amides for mycobacterium infections Pyridine carboxylic acid amides for mycobacterium infections

1975-06-03

1976-11-30

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424246, 424250, 424251, 424258, 424262, 424267, 424269, 424270, 424272, 424274, 424275, 424276, 424278, 424283, 424285, 260302A, 260307R, 260307H, 260308A, 260308B, 260309, 260239BF, 260213R, 2603096, 260243B, 260244R, 260310R, 2602472A, 260250B, 260326A, 260250Q, 260251R, 2603261, 260265, 260287R, 2603262, 260287D, 260295AM, 260327R, 260295B, 260302R, 2603322A, 260333, 2603402, 2603457, 2603473, A61K 3144

Patent

active

039950441

ABSTRACT:
Benzoic acid amides characterized by the presence of a nitro, cyano, trifluoromethyl, alkylsulfonyl, carboxy, carbalkoxy, amido or sulfonamido substituent in the phenyl ring and by the presence of a heterocyclic group connected to the amide nitrogen atom through a hydrocarbon chain are antibacterial agents and in particular antituberculosis agents. The compounds, of which N-(pyrid-2-yl-methyl)3,5-dinitrobenzoic acid amide is a typical embodiment, are prepared by the reaction of an appropriately substituted benzoic acid, or derivative thereof, with an appropriate amine.

REFERENCES:
patent: 3270026 (1966-08-01), Berger et al.
patent: 3367940 (1968-02-01), Hotten
patent: 3439019 (1969-04-01), Sarett et al.
patent: 3455940 (1969-07-01), Stecker
patent: 3509166 (1970-04-01), Wright, Jr. et al.
patent: 3676447 (1972-07-01), Skinner et al.

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