Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-30
1994-07-26
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546316, 546323, 514354, C07D21302, A61K 3144
Patent
active
053327519
ABSTRACT:
Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represent .dbd.N-- or .dbd.CH--, E represents an aromatic 6-membered cyclic group, which may have 1 or 2 nitrogen atoms in the ring, and be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination of R.sup.1 which is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R.sup.2 and R.sup.3 which are each a hydrogen atom, A and B which are each .dbd.CH-- and E which is a phenyl group which may be substituted with 1 to 3 substituents G which may be the same or different from one another is excluded,
or pharmacologically acceptable salts of them, have an excellent antitumor activity.
REFERENCES:
Baxter et al., J. of Chemical Society, Section C, pp. 850-853, 1970.
Chemical Abstracts, vol. 96, No. 21, Abstract 190,694q, p. 672, May 24, 1982.
Asada Makoto
Iijima Atsumi
Kitoh Kyosuke
Kotake Yoshihiko
Koyanagi Nozomu
Davis Zinna N.
Eisai Co. Ltd.
Ivy C. Warren
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