Pyridine and thiazolidinedione derivatives

Details Pyridine and thiazolidinedione derivatives Pyridine and thiazolidinedione derivatives

1997-10-10

2000-02-15

Stockton, Laura L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546340, C07D21346, C07D41712

Patent

active

RE0365750

ABSTRACT:
A compound of the formula: ##STR1## (wherein R.sup.1 is hydrogen or a lower alkyl) can be produced advantageously by (1) reacting a compound of the formula: ##STR2## (wherein R.sup.1 has the meaning given above) with a halogenating agent or sulfonyl halide to give a compound of the formula: ##STR3## (wherein R.sup.1 has the meaning given above and X is a halogen or an alkyl- or aryl-sulfonyloxy), (2) reacting the resulting compound with a compound of the formula: ##STR4## to give a compound of the formula: ##STR5## (wherein R.sup.1 has the meaning given above), (3) reacting the resulting compound with a compound of the formula: ##STR6## to give a compound of the formula: ##STR7## (wherein R.sup.1 has the meaning given above), and (4) subjecting the resulting compound to catalytic reduction.

REFERENCES:
patent: 4687777 (1987-08-01), Meguro et al.
patent: 4725610 (1988-02-01), Meguro et al.
Sohda et al., Chem. Abstracts, vol. 98, No. 19; 160624h (1983).
March, J. Adv. Org. Chem., pp. 707-709. Month and Year Not Available.
Sohda et al., "Studies on Antidiabetic Agents. III..sup.1) 5-Arylthiazolidine-2,4-diones as Potent Aldose Reductase Inhibitors", Chem. Pharm. Bull. 30(10)3601-3616(1982).

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