Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-01-29
2008-01-29
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252140, C514S275000, C544S122000, C544S295000, C544S323000
Reexamination Certificate
active
07323464
ABSTRACT:
Compounds of formula (1) are described in which Raand Rbis each independently a hydrogen atom or a group Rc, or Raand Rbtogether form an oxo (═O) or thio (═S) group; X is a N atom or an optionally substituted CH group: Y is a —O— or —S— atom or —SO— or —SO2— group or an optionally substituted —CH2— or —NH— group with the proviso that when Raand Rbtogether form an oxo (═O) or thio (═S) group Y is an optionally substituted —CH2— or —NH-group; L1is a covalent bond or a linker atom or group; p is zero or the integer 1; Alk1is an optionally substituted C1-10aliphatic or C1-10heteroaliphatic chain; n is zero the integer 1, 2 or 3 with the proviso that when n is zero Y is an optionally substituted —CH2— group; Ar is an optionally substituted C6-12aromatic or C1-9heteroaromatic group; m is zero or the integer 1, 2 or 3; q is zero or the integer 1 or 2; R1, Rcand Rdare hydrogen atoms or the substituents described in the patent specification; and the salts, solvates, hydrates and N-oxides thereof. The compounds are potent and selective inhibitors of p38 kinase and are useful in the treatment of immune or inflammatory disorders.
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Brookings Daniel Christopher
Cubbon Rachel Jane
Davis Jeremy Martin
Franklin Richard Jeremy
Langham Barry John
Celltech R&D Limited
McDonnell Boehnen & Hulbert & Berghoff LLP
Rao Deepak
LandOfFree
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