Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-03-08
2011-03-08
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S350000
Reexamination Certificate
active
07902195
ABSTRACT:
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I:wherein R2, R6A, R6Band R8are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.
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J. N. Ren, et al.,The PDE5 Inhibitor Sildenafil Improves Functional Recovery after Middle Cerebral Artery Occlusion in Rats: Mechanism of Action, 582.15,Society for Neuroscience, 36thAnnual Meeting 2006.
Green, T., et al.,Protecting Groups in Organic Synthesis, John Wiley & Sons, Inc., Second Edition, Chapter 7,pp. 309-405, 1991.
Miyaura, N., et al.,Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds, Chem Rev. 95, pp. 2457-2483, 1995.
Ley, S., et al.,Modern Synthetic Methods for Copper-Mediated C9aryl)-O,C(alyl)-N, and C(aryl)-S Bond Formation, Angew. Chem. Int. Ed., 42, pp. 5400-5449, 2003.
Thompson, W. J., et al.,Purification and Characterization of High-Affinity Cyclic Adenosine Monophosphate Phosphodiesterase from Dog Kidney, Biochemistry 18(23), pp. 5228-5237, 1979.
Ballard, S.A., et al.,Effects of Sildenafil on the Relaxation of Human Corpus Cavernosum Tissue in Vitro and on the Activities of Cyclic Nucleotide Phosphodiesterase Isozymes, J. Urology 159(6), pp. 2164-2171, 1998.
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Bell Andrew Simon
Brown David Graham
Brown David L.
Fobian Yvette M.
Freskos John N.
Kispert Jennifer A.
McDowell Brian
Pharmacia & Upjohn Company LLC
Ronau Robert T.
Wilson James O
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