Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-08-23
2005-08-23
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S333000, C544S335000, C546S323000
Reexamination Certificate
active
06933298
ABSTRACT:
Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides of formula I. These compounds are found to possess the property of selectively inhibiting collagenase (MMP). They may therefore be useful in prophylaxis and therapy of diseases whose course involves an increased activity of matrix metalloproteinase 13.
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Massova, I. et al., Matrix Metalloproteinases: Structures, Evolution, and Diversification, The FASEB Journal, 1998, (12), pp. 1075-1095.
Veb Deutscher Verlag der Wissenschaften, Methodenregister, Organikum, Organisch Chemisches Grundpraktikum, 15. Aufl., 1976, p. 822.
Weithmann, K.U. et al., Effects of Tiaprofenic Acid on Urinary Pyridinium Crosslinks in Adjuvant Arthritic Rats: Comparison with Doxycycline, Inflammation Research, 1997, (46), pp. 246-252.
Habermann Jörg
Kirsch Reinhard
Kogler Herbert
Wehner Volkmar
Weithmann Klaus-Ulrich
Aventis Pharma Deutschland GmbH
Berch Mark L.
Habte Kahsay
Rossi Joseph D.
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