Pyridazo[1,2]pyridazines and pyrazolo[1,2]pyridazines as antihyp

Details Pyridazo[1,2]pyridazines and pyrazolo[1,2]pyridazines as antihyp Pyridazo[1,2]pyridazines and pyrazolo[1,2]pyridazines as antihyp

1986-11-28

1988-09-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544232, C07D48706

Patent

active

047727012

ABSTRACT:
Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R.sup.1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl, dialkylamino-alkyl, acylamino-alkyl, phthalimido-alkyl, alkoxycarbonylamino-alkyl, aryloxycarbonylamino-alkyl, aralkoxycarbonylamino-alkyl, alkylaminocarbonylamino-alkyl, arylaminocarbonylamino-alkyl, aralkylaminocarbonylamino-alkyl, alkylsulphonyl-amino-alkly or arylsulphonylamino-alkyl group, R.sup.2 represents a carboxyl, alkoxycarbonyl or aralkoxycarbonyl carbonyl group or a group of the formula ##STR2## R.sup.3 represents a carboxyl, alkoxycarbonyl or aralykoxycarbonyl group, R.sup.4 and R.sup.5 each represent a hydrogen atom or R.sup.4 and R.sup.5 together represent an oxo group; R.sup.6 and R.sup.7 each represent a hydrogen atom or an alkyl or aralkyl group or R.sup.6 and R.sup.7 together with the nitrogen atom to which they are attached represent a 5-membered or 6-membered heteromonocyclic ring which may contain a further nitrogen atom or an oxygen or sulphur atom, and n stands for zero, 1 or 2,
and pharmaceutically acceptable salts thereof have antihypertensive activity and can be used as medicaments in the form of pharmaceutical preparations.

REFERENCES:
patent: 4307094 (1981-12-01), Hassall et al.
patent: 4341781 (1982-07-01), Hassall et al.
patent: 4487929 (1984-12-01), Hassall et al.
Attwood et al., CA 100-139 158j.
Hassall et al., CA 96-199715x.
Pharm. Acta. Helv. 1964, 39(3), pp. 151-161.

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