Pyridazo (1,2-a) (1,2) diazepine derivatives

Details Pyridazo (1,2-a) (1,2) diazepine derivatives Pyridazo (1,2-a) (1,2) diazepine derivatives

1986-06-23

1988-05-10

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540500, 544 61, 544116, 544232, 544235, 544236, 544224, 514221, C07D48704, C07D23704, A61K 3150, A61K 3155

Patent

active

047436875

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 represents hydroxy, alkyl, aralkyl, aralkoxy-alkyl, hydroxy-alkyl, amino-alkyl, acylamino-alkyl, monoalkylamino-alkyl, dialkylamino-alkyl, alkoxycarbonylamino-alkyl, halo-alkyl, carboxy-alkyl, alkoxycarbonyl-alkyl, alkoxy or aralkoxy; R.sup.2 and R.sup.3 each represent hydrogen, alkyl or aralkyl; R.sup.4 and R.sup.5 each represent hydrogen or R.sup.4 and R.sup.5 together represent oxo; and X represents an oxygen atom or the group --NR.sup.6 -- in which R.sup.6 represents hydrogen, alkyl or aralkyl or --(CH.sub.2).sub.n -- in which n stands for zero, 1 or 2,
and racemates, enantiomers, diastereoisomers or pharmaceutically acceptable salts thereof have antihypertensive activity and can be used as medicaments in the form of pharmaceutical preparations. They can be prepared according to known methods.
Compounds useful as starting materials for producing the compounds of formula I are also provided.

REFERENCES:
patent: 4307094 (1981-12-01), Hassall et al.
patent: 4341781 (1982-07-01), Hassall et al.
patent: 4399136 (1983-08-01), Hassall et al.
patent: 4512924 (1985-04-01), Atwood et al.
patent: 4692438 (1982-09-01), Hassall et al.

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