Pyridazinones having cardiotonic and beta blocking activities

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142358, 544114, 544239, 544163, A61K 3150, A61K 31535, C07D23714

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active

050969048

ABSTRACT:
Pyridazinones of the following formula (I): ##STR1## where R.sup.1 -R.sup.4 are a variety of substituents and L is a linking group, a pharmaceutical composition for treating congestive heart failure, novel intermediates, methods for such treatment and processes for preparing compounds of formula (I).

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patent: 4652563 (1987-03-01), Slater
patent: 4711887 (1987-12-01), Briggs et al.
patent: 4843072 (1989-06-01), Yasuda et al.
Buorger, "Medicinial Chemistry", 2d ed., Interscience, New York, (1960), p. 42.
R. A. Slater, J. Med. Chemistry, vol. 31, No. 2, pp. 345-356 (1988).
W. V. Curran et al., J. Med. Chemistry, vol. 17, No. 3, pp. 273-281 (1974).

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