Pyridazinones

Details Pyridazinones Pyridazinones

1974-11-11

1976-08-17

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602472A, 260239BA, 260268C, 260268PH, 2602938, 260295R, 26032641, 260473R, 260521R, 260519, 2602472R, 424248, 424250, C07D23704

Patent

active

039753883

ABSTRACT:
Compounds of the general formula: ##SPC1##
In which X represents a straight or branched chain alkyl or alkoxy group, a hydroxymethyl group, a cycloalkyl group, a cycloalkoxy group, an aryloxy group, a hydroxyl group, a fluorine atom, a chlorine atom, an amino or substituted amino group, a piperidino group, a morpholino group, a pyrrolidino group, a 1,2,3,6-tetrahydropyridino group, a 4-[3-azabicyclo(3,2,2)-nonyl] group, or a 4-(piperazin-1-yl) or 4-(4-substituted-piperazin-1-yl) group of the formula ##SPC2##
In which R=H, lower alkyl or 1-5 carbon atoms, aryl, substituted aryl, aralkyl, cinnamyl, acyl, ethoxy-carbonyl, aroyl or substituted aroyl and n is an integer from 1 to 5 except that when n is 1 X is not an alkyl group of 1 to 3 carbon atoms or an alkoxy group of 1 or 2 carbon atoms or a chlorine atom in the 4'-position, or an amino or acylated amino group in positions 2', 3' or 4'; and when n = 2 the groups X cannot both be methyl or both be methoxy in the 2' and 5' positions, nor can X be a chlorine atom in both the 2' and 4' positions or the 3' and 4' positions, and when n = 3, X cannot all three be methoxy. These compounds have anti-hypertensive activity.

REFERENCES:
Nour et al., Pyridazines, Part I, The Synthesis of 6-aryl-4,5-dihydro-3 hydroxy-4-pyridazinylideneglycollohydrazides, Journal of Chemical Society 1964 (Dec.) 5302-5306.
Berichte, 1899, 32, pp. 395-409.

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