Pyridazinone derivatives, processes for production thereof and u

Details Pyridazinone derivatives, processes for production thereof and u Pyridazinone derivatives, processes for production thereof and u

1994-12-15

1997-02-18

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544240, 544241, C07D23716

Patent

active

056042264

ABSTRACT:
Pyridazinone derivatives of formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group which may be substituted with an aliphatic cyclic amino group optionally containing a hetero atom in the ring thereof; each of X.sup.1 and X.sup.2 independently represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a cyano group, a nitro group or a group shown by --CO--NR.sup.2 R.sup.3 (wherein each of R.sup.2 and R.sup.3 independently represents an alkyl group having 1 to 6 carbon atoms); Y represents a halogen atom; Z represents an alkoxy group having 1 to 6 carbon atoms; l represents 0 or an integer of 1 to 3; A represents CH or N; m represents 0 or an integer of 1 or 2; and n represents an integer of 1 to 8, exhibit a platelet aggregation inhibiting activity and are useful for the treatment of circulatory disorders such as cerebral infarction.

REFERENCES:
patent: 4978665 (1990-12-01), Tanikawa et al.
patent: 5011839 (1991-04-01), Tanikawa et al.
patent: 5314883 (1994-05-01), Tanikawa et al.

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