Pyridazinone derivatives and processes for preparing the same

Details Pyridazinone derivatives and processes for preparing the same Pyridazinone derivatives and processes for preparing the same

1996-12-16

1998-04-14

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 544238, 544239, 544114, A61K 3150

Patent

active

057391327

ABSTRACT:
Disclosed are a pyridazinone compound represented by the formula: ##STR1## wherein (1) R.sup.1 is a substituted or unsubstituted C.sub.1-10 alkyl, a C.sub.3-6 cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R.sup.3 is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R.sup.1 and R.sup.3 are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula: ##STR2## where n is 1 or 2; and D is hydrogen or a halogen; or (2) R.sup.1 is a substituted or unsubstituted C.sub.1-10 alkyl, a substituted or unsubstituted phenyl, a C.sub.3-6 cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R.sup.3 is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R.sup.1 and R.sup.3 are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula: ##STR3## and R.sup.2 is hydrogen, a substituted or unsubstituted lower alkyl, an aryl or a lower alkenyl; and --A--B-- is an ethylene or vinylene each of which may be substituted by 1 or 2 groups selected from the group consisting of a lower alkyl and phenyl group,
or a pharmaceutically acceptable salt thereof, and processes for preparing the same.

REFERENCES:
patent: 2712012 (1955-06-01), Clark et al.
patent: 4374990 (1983-02-01), Weber et al.
patent: 4820705 (1989-04-01), Nickl et al.
patent: 5179018 (1993-01-01), Bogard, Jr. et al.
patent: 5409956 (1995-04-01), Yoshida et al.
patent: 5543409 (1996-08-01), Ishida
patent: 5605901 (1997-02-01), Ishida
Dorland's Illustrated Medical Dictionary, 26th Ed., pp. 874 and 1080.
Chem Abstract 108, 186330 (1988).
Chem Abstract V.116, No. 128652V (1992).

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