Pyridazinedione derivatives useful in treatment of neurological

Details Pyridazinedione derivatives useful in treatment of neurological Pyridazinedione derivatives useful in treatment of neurological

1995-10-19

1997-07-29

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544234, 544236, 548492, 560 43, 564311, A61K 3150, C07D48704, C07D49514, C07D47114

Patent

active

056522398

ABSTRACT:
The present invention relates to pyridazino[4,5-b]indoles, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]indoles as active ingredient, and methods for the treatment of neurological disorders.

REFERENCES:
Monge et al J. Med. Chem., 34, 3023-3029 (1991).
Monge et al Acta Farm. Bonaerense, 3(1), 21-6 (1984).
Monge-Vega et al. J. Pharm. Sci, 71(12), 1406-8, (1982).
Monge-Vega et al. J. Heterocyclic Chem., 18, 1533 (1981).
Kurasawa et al., "A Convenient Synthesis of Pyridazino[4,5-b]quinolines and Pyrrolo[3,4-b]quinolines" Chem. Pharm. Bull., (1980) 28, No. 12, 3457-3465.
Ferguson et al., "Selected Pharmacological Studies of a Series of Substitued Imidazo(4,5-d)pyridazines" J. Pharm. Sci., (1970) 59, No. 11, 1584-1586.

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