Pyridazine derivatives active on the central nervous system, and

Details Pyridazine derivatives active on the central nervous system, and Pyridazine derivatives active on the central nervous system, and

1985-10-03

1988-01-26

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514248, 544224, 544238, 544239, C07D41312, A61K 31535

Patent

active

047217111

ABSTRACT:
The invention relates to the pyridazine derivatives of the formula: ##STR1## in which R.sub.1 is H, a substituted or unsubstituted phenyl group, a naphthyl group, a cyclohexyl group, a thien-2-yl group, a thien-3-yl group or an indol-3-yl group, R.sub.2 is H or an alkyl or phenyl group, R.sub.3 is H, an alkyl, or phenyl group in formula Ib and a cyano group in formula Ia, and Alk is (CH.sub.2).sub.n where n is 2, 3 or 4, or --CH.sub.2 --C.ident.C--, and X.sup.- is halide, a process for the preparation of the said products and their application as medicaments.

REFERENCES:
patent: 4508720 (1985-04-01), Kan et al.
patent: 4514397 (1985-04-01), Wermuth et al.
patent: 4565814 (1986-01-01), Kan et al.
patent: 4576946 (1986-03-01), Wermuth et al.
Chambon et al., Proc. Natl. Acad. Sci. USA, vol. 82, pp. 1832-1836, Mar. 1985.
Roberts et al., "Basic Principles of Organic Chemistry", p. 556.
Le Clerc et al., Eur. J. Med. Chem. 1976-11, No. 2, pp. 107 to 113.

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