Pyrazolyl inhibitors of 15-lipoxygenase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S224000, C544S336000, C548S356100, C548S364100, C514S252100, C514S403000, C514S406000

Reexamination Certificate

active

07432271

ABSTRACT:
The present invention provides pyrazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

REFERENCES:
U.S. Appl. No. 10/932,594, filed Sep. 1, 2004, Weinstein et al.
U.S. Appl. No. 10/932,457, filed Sep. 1, 2004, Weinstein.
Bleich, D., et al., “Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice”, The Journal of Clinical Investigation, vol. 103, No. 10, pp. 1431-1436, May 1999.
Bocan, T., et al., “A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophase enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit”, Atherosclerosis, vol. 136, pp. 203-216, 1998.
Kelavkar, U. et al., “The Effect of 15-Lipoxygenase -1 Expression on Cancer Cells”, Current Urology Reports, vol. 3, pp. 207-214, 2002.
Setty, B.N., et al., 15-Hydroxyeicosatetraenoic Acid-Medicated Potentiation of Thrombia-Induced Platelet Functions Occurs Via Enhanced Production of Phosphoinositide-Derived Second Messengers—sn-1,2-Diacylglycerol and Inositol-1,4,5-Trisphosphate, Blood., vol. 80, No. 11, pp.
Sultana, S., et al., “Lipoxygenase Metabolites Induced Expression of Adhesion Molecules and Transendothelial Migration of Monocyte-Like HL-60 Cells Is Linked to Protein Kinase C Activation”, Journal of Cellular Physiology, vol. 167, pp. 477-487, 1996.
Tisdale, M.J., “Protein Loss in Cancer Cachexia”, Science's Compass, vol. 289, pp. 2293-2294. 2000.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pyrazolyl inhibitors of 15-lipoxygenase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrazolyl inhibitors of 15-lipoxygenase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazolyl inhibitors of 15-lipoxygenase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3992955

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.