Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-12-15
1997-01-21
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 82, C07D47114, C07D48714, A61K 3144
Patent
active
055959989
ABSTRACT:
The invention relates to compounds of the formulas ##STR1## wherein X, R.sub.1, R.sub.2, and R.sub.3, are as described herein. These compounds are useful as antitumor agents. Pharmaceutical compositions containing compounds of formula I are also described. Methods for treating tumors which comprise administration of compounds of formula I are also described. Processes for preparing compounds of formula I are also described.
REFERENCES:
Nucleic Acids Research, vol. 17, No. 15 (1989) pp. 6129-6141.
Chem. Lett. (1978)(6) pp. 605-608 (a computer printout of an abstract is enclosed).
J. Org. Chem. (1968) 33(5), 1806-10 (a computer printout of an abstract is enclosed).
Afonso Adriano
Kelly Joseph M.
Njoroge F. George
Wolin Ronald L.
Boxer Matthew
Maitner John
Rotman Alan L.
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