Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-09-12
1993-03-09
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 82, C07D47104, A61K 3144
Patent
active
051927683
ABSTRACT:
A pyrazoloquinoline derivative having the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent a hydrogen atom or a lower alkyl group; R.sup.4 represents a hydrogen atom, a lower alkyl group, a halogen-substituted lower alkyl group, or a lower alkoxycarbonyl group; the dotted line means that the pyrazole ring has two conjugated double bonds; and R.sup.4 is bonded to the nitrogen atom at the 1-position or 2-position, or pharmacologically acceptable salts thereof. These compounds exhibit excellent anti-inflammatory activity and hepatic insufficiency treating activity.
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patent: 4524146 (1985-06-01), Yokoyama
patent: 4675324 (1987-06-01), Ueda et al.
patent: 4748246 (1988-05-01), Skotnicki et al.
Kumar, et al., J. Chem. Soc. Perkin Trans I, (8), pp. 857-862 (1978).
Hosoe Hisashi
Kubo Kazuhiro
Nakasato Yoshisuke
Ohmori Kenji
Suzuki Fumio
Kyowa Hakko Kogyo Co. Ltd.
Rotman Alan L.
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