Pyrazoloquinazolone derivatives as neurotrophic agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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544247, 544251, 544 89, 544 90, 544 91, 544 94, 540578, 435 71, 435 721, 435 723, 548251, 5483697, C07D48704, C07D48714, C07D491147, C07D49514

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active

053429427

ABSTRACT:
Pyrazolo[5,1-b]quinazoline compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds, and methods for treating neurodegenerative disorders, tumors of neuronal origin, inflammation, allergy, and pain, and methods for screening compounds that interact with the neurotrophic receptors using said compositions are disclosed.

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Sircar et al., J. Med. Chem. 24, pp. 735-742 (1981).
Tachibana et al., Chemical Abstracts, vol. 112, No. 207749 (Abstract for JP 01210950 Aug. 24, 1989) (1990).
Medicinal Chemistry (2nd Ed.) by Alfred Burger, pp. 72-75 and 79-80 (1960).
J. C. Sircar, T. Capiris, S. J. Kesten, J. Heterocycl. Chem. 1981, (18), 117-121.

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