Pyrazolopyrrolidines as inhibitors of gamma secretase

Details Pyrazolopyrrolidines as inhibitors of gamma secretase Pyrazolopyrrolidines as inhibitors of gamma secretase

2011-07-12

2011-07-12

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S360000, C514S408000, C514S422000, C548S122000, C548S400000, C548S416000, C548S418000, C548S518000

Reexamination Certificate

active

07977368

ABSTRACT:
The invention provides compounds of Formula Iwherein A, Y, R1, R1a, R2, and R2aare as described in the specification. Compounds of Formula I are useful in treating and/or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of preparing compounds of Formula I, and methods of treating cognitive disorders, such as Alzheimer's disease.

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