Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine...

Details Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine... Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine...

2005-07-12

2005-07-12

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S366000

Reexamination Certificate

active

06916927

ABSTRACT:
Compounds of formulae (IA) and (IB) or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein R1is C1to C3alkyl substituted with C3to C6cycloalkyl, CONR5R6or a N-linked heterocyclic group; (CH2)nHet or (CH2)nAr, R2is C1to C6alkyl; R3is C1to C6alkyl optionally substituted with C1to C4alkoxy; R4is SO2NR7R8; R5and R6are each independently selected from H and C1to C4alkyl optionally substituted with C1to C4alkoxy, or, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic group; R7and R8, together with the nitrogen atom to which they are attached, form a 4-R10-piperazinyl group; R10is H or C1to C4alkyl optionally substituted with OH, C1to C4alkoxy or CONH2; Het is an optionally substituted C-linked 5- or 6-membered heterocyclic group; Ar is optionally substituted phenyl; and n is 0 or 1; are potent and selective cGMP PDE5 inhibitors useful in the treatment of, inter alia, male erectile dysfunction and female sexual dysfunction

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