Pyrazolopyrimidine compositions

Details Pyrazolopyrimidine compositions Pyrazolopyrimidine compositions

2006-08-29

2006-08-29

Jones, Dwayne C. (Department: 1614)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S280000, C514S259300

Reexamination Certificate

active

07098335

ABSTRACT:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

REFERENCES:
patent: 4178449 (1979-12-01), Dusza et al.
patent: 5571813 (1996-11-01), Ruhter et al.

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