Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-

Details Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti- Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-

1993-12-28

1995-03-14

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 86, 544243, 544244, 544281, A61K 31675, C07F 96512, C07F 96574, C07F 96561

Patent

active

053977742

ABSTRACT:
Compounds useful in the treatment of inflammation structurally represented as ##STR1## wherein X is O or S and the R groups are as herein defined. The compounds are useful as anti-inflammatory and anti-arthritic agents without inhibiting prostaglandin synthesis.

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patent: 4871720 (1989-10-01), Jaeggi
patent: 5071840 (1991-12-01), Ebetino et al.
Nugent et al, Chemical Abstracts, vol. 118, No. 255 119 (1993) (Abstract for EP 521622).
Nugent et al American Chemical Society spring meeting on Jun. 9, 1988, PD 7244-88-021.
Sietsema et al Chemical Abstracts No. 191396, vol. 112, No. 21, May 21, 1990.
Sietsema et al Drug Exp. Clin. Res., vol. 15, No. 9, pp. 389-396, 1989.

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