Pyrazolopyridines and salts thereof, a pharmaceutical...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07842809

ABSTRACT:
The invention relates to pyrazolopyridines according to the general formula (I):and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with angiopoietin and therefore influence Tie2 signalling.

REFERENCES:
patent: 7297709 (2007-11-01), Dai et al.
patent: 7323472 (2008-01-01), Adams et al.
patent: WO 0119828 (2001-03-01), None
patent: WO 2004113304 (2004-12-01), None
El-Semary, Mona M.A. et al., “Synthesis and Biological Evaluation of Some Pyridine Derivatives as Potential Cardiotonic Agents,” Alexandria Journal of Pharmaceutical Sciences, 2003, pp. 59-63, vol. 17, No. 1, XP008062291.
Abdalla, M. et al., “Synthesis and Reaction of 3-Cyano 2-(1H)-Pyridones,” Pakistan J. Ind. Res., 1977, pp. 139-149, vol. 20, No. 3, XP008062289.
Elneairy M. A. A., “Cyanothioacetamide in Heterocyclic Synthesis . . . ” Phosphorus, Sulfur and Silicon and the Related Elements, Gordon and Breach Science publishers, Amsterdam, GB, 2003, pp. 2201-2214, vol. 178, No. 10, XP008040312.

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