Pyrazolopyridine derivatives and their use as anti-inflammatory

Details Pyrazolopyridine derivatives and their use as anti-inflammatory Pyrazolopyridine derivatives and their use as anti-inflammatory

1985-01-23

1986-03-18

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546119, A61K 31415, A61K 3144, C07D47104

Patent

active

045769524

ABSTRACT:
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl;

REFERENCES:
Hylton Foster and Jim Hurst, J. Chem. Soc. Perkin Trans I, 1976 (5), 507-512.
Hylton Foster and Jim Hurst, J. Chem. Soc. Perkin Trans I, 1973, 2901.
E. Ajello, "New Synthesis of Condensed Heterocycles from Isoxazole Derivatives. II. Pyrazolo[4,3-b]pyridine", J. Heterocycl. Chem., 8, pp. 1035-1037 (Dec. 1971).
F. M. Dietrich et al., Hypersensitivity in Mice. I. Induction of Contact Sensitivity to Oxazolone and Inhibition by Various Chemical Compounds", Int. Arch. Allergy, 38:246-259 (1970).
H. E. Foster et al., "Pyrazolopyridines. Part IV. Preparation and Tautomerism of 6-Cyano- and 6-Ethoxycarbonyl-1, 4-dihydropyrazole[4, 3-6]Pyridin-7-Ones", J. Chem. Soc., Perkin Trans. I, 5, pp. 507-512 (1976).
B. A. Jakschik et al., Calcium Stimulation of a Novel Lipoxygenase", Biochem. Biophys. Res. Comm., 95:103-110 (1980).
K. F. Swingle et al., "Comparison of Croton Oil and Contharidin Induced Inflammations of the Mouse Ear and their Modification by Topically Applied Drugs", Arch. Int. Pharmacodyn., 254:168-176 (1981).

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