Pyrazoloisoquinoline derivative as kinase inhibitors for the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S292000, C514S269000, C546S082000

Reexamination Certificate

active

07132428

ABSTRACT:
Compounds of the formula Iare suitable for producing pharmaceuticals for the prophylaxis and therapy of diseases whose course involves an increased activity of NIK.

REFERENCES:
patent: 4748246 (1988-05-01), Skotnicki et al.
patent: 6841556 (2005-01-01), Flohr et al.
patent: 1134221 (2001-09-01), None
patent: 2185255 (1987-07-01), None
patent: WO 02/44153 (2002-06-01), None
patent: WO 03/024936 (2003-03-01), None
Yumi Yamamoto et al., Role of the NF-kB Pathway in the Pathogenesis of Human Disease States, Current Molecullar Medicine (2001, pp. 287-296, vol. 1).
Lucia Cecchi et al., Synthesis of 1,5-Diaryl-3-Methyl-1 H-pyrazolo(4,5-c) Isoquinolines And Studies of Binding to Specific Peripheral Benzodiazepine Binding Sites, Journal of Pharmaceutical Sciences (1989, pp. 437-442, vol. 78, No. 6).

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