Pyrazolo-quinoline derivatives for treating cerebral ischemia

Details Pyrazolo-quinoline derivatives for treating cerebral ischemia Pyrazolo-quinoline derivatives for treating cerebral ischemia

1995-04-24

1996-12-03

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 82, A61K 3144, C07D47104

Patent

active

055808778

ABSTRACT:
A class of 3,5-dihydro-1H-pyrazolo[3,4-c]quinoline-1,4(2H)-dione derivatives, substituted in the 2-position by an optionally substituted phenyl moiety, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment and/or prevention of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA antagonist.

REFERENCES:
patent: 5071859 (1991-12-01), Knudsen
patent: 5399696 (1995-03-01), Arnold
Helv. Chim. Acta, (1928), vol. 11, p. 242.
Nagarajan et al. "Condensed Heterotricyles: Synthesis of pyrazolo[3,4-c]quinoline derivatives", Indian Jour. of Chem. vol. 31B, 1992, pp. 316-321.
Petracek FJ. in "Principles of Psychopharmacology" W.G. Clark & J. del Giudance eds. (1970) Academic Press NY. pp. 166-167.

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