Pyrazolo-pyridinone compounds and methods of use thereof

Details Pyrazolo-pyridinone compounds and methods of use thereof Pyrazolo-pyridinone compounds and methods of use thereof

2008-05-06

2010-12-07

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S119000

Reexamination Certificate

active

07846944

ABSTRACT:
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula Iwherein A1, A2, A3, A4, B, R1, R2, R3, R4and R5are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

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