Pyrazolo[3,4-d]pyrimidines with adenosine-like binding affinitie

Details Pyrazolo[3,4-d]pyrimidines with adenosine-like binding affinitie Pyrazolo[3,4-d]pyrimidines with adenosine-like binding affinitie

1991-06-19

1993-07-13

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

536 276, C07D48704

Patent

active

052274853

ABSTRACT:
The A21 receptor extracelluar site and the A2 receptor extracellular site of adenosine analogues are structurally different and that binding orientations of adenosine or adenosine analogues are different at these sites and this may be used to determine their structure. Novel pyrimidine compounds are described.

REFERENCES:
Tominaga et al., J. Heterocyclic Chem., 27, 775-783 (1990).
Quinn et al., Aust. J. Chem., 44, 753-757 (1991).
Brown et al., Aust. J. Chem., 32, 453-458 (1979).
Davies et al. (I), Eur. J. Pharmacology, 97, 325-329 (1984).
Davies et al. (II), Life Sci., 34(22), 2117-2128 (1984).
Davies et al. (III), Neurosci Lett., 41(1-2), 189-193 (1983).

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