Pyrazolo[3,4- b ]pyridine compounds, and their use as PDE4...

Details Pyrazolo[3,4- b ]pyridine compounds, and their use as PDE4... Pyrazolo[3,4- b ]pyridine compounds, and their use as PDE4...

2005-03-15

2008-12-16

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S120000

Reexamination Certificate

active

07465743

ABSTRACT:
The invention relates to a compound of formula (I) or a salt thereof:wherein: R1is Et, n-Pr, i-Pr, C2fluoroalkyl, or —CH2CH2OH;R2is H, Me, Et, n-Pr, i-Pr, C1-2fluoroalkyl, cyclopropyl or (cyclopropyl)methyl-; and NHR3has the sub-formula (nhr3):wherein R3ais methyl or ethyl; R3bis H, methyl or ethyl; R3cis H, methyl or ethyl, R3dis H, methyl or ethyl, and R3eis H or methyl,provided that: (a) R3bis methyl or ethyl; and/or (b) R3cand R3dare independently methyl or ethyl; and provided that: (c) when R3cis ethyl and/or when R3dis ethyl and/or when R3eis methyl, then: R3ais methyl and/or R3bis hydrogen or methyl.These compounds are PDE4 inhibitors.

REFERENCES:
patent: 3840546 (1974-10-01), Hoehn et al.
patent: 3925388 (1975-12-01), Hoehn et al.
patent: 4072681 (1978-02-01), Denzel et al.
Hohn H et al: “Potential Antidiabetic Agents. Pyrazolo ′3,4-b!pyridines” Journal of Medicinal Chemistry, American—Chemical Society. Washington, US, vol. 16, No. 12, 1973, pp. 1340-1346, XP002097814, ISSN: 0022-2623, p. 1343; compound 37.
Patent Abstracts of Japan, vol. 2002, No. 05, May 3, 2002-& JP 2002 020386 A (ON0 Pharmaceut Co Ltd), Jan. 23, 2002 cited in the application abstract.

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