Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors

Details Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors Pyrazolo[3,4-b]pyridin-6-ones as GSK-3 inhibitors

2007-11-27

2007-11-27

Davis, Zinna N. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S119000

Reexamination Certificate

active

10875009

ABSTRACT:
The present invention provides compounds of formula (I)the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R1, R2and R3are as defined herein; pharmaceutical formulations thereof; and use thereof in the treatment of, inter alia, conditions, diseases, and symptoms such as bipolar disorder, diabetes, dementia, Alzheimer's Disease, stroke, schizophrenia, depression, hair loss, and cancer.

REFERENCES:
patent: 2002/0103185 (2002-08-01), Sanner et al.
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker (Modern Pharmaceutics) Banker, G.S. et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
Quiroga, J. et al., Heterocyclic Comm., vol. 5(2), pp. 115-122, 1999, “Sythesis, Molecular Structure and Tautomerism of 1(2)H-Dihidropyrazolo[3,4-b]Pyridin-6-Ones.”
Catarzi, D. et al., Arch. Pharm. Pharm. Med. Chem., vol. 300, pp. 383-386, 1997, “Tricyclic Heteroaromatic Systems. Pyrazolo[3,4-c]quinolin-4-ones and Pyrazolo[3,4-c]quinoline-1,4-diones: Synthesis and Benzodiazepine Receptor Activity.”

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