Pyrazolo[1,5a]pyrimidine compounds as antiviral agents

Details Pyrazolo[1,5a]pyrimidine compounds as antiviral agents Pyrazolo[1,5a]pyrimidine compounds as antiviral agents

2007-03-27

2007-03-27

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S403000, C514S406000, C546S001000, C546S026000, C546S112000, C546S134000, C548S356100, C548S358100, C548S360100

Reexamination Certificate

active

10452400

ABSTRACT:
The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.

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Abdel-Maksoud, F., “Reactions with 5-aminopyrazoles: Synthesis of some new pyrazolo(1,5-a)pyrimidines”,Mans. Sci. Bull. (A Chem.), 23(1): 49-54; XP009016327 p. 52, compounds 5b, 5c, 5e, 5f.
Kolehmainen, E. et al., “Spectral Assignments and Reference Data”,Magn. Res. Chem., 40:480-482 (May 23, 2002); XP009016326 Scheme 1, compounds 1-10.
Orlov, V. D. et al., “Aryl-substituted 6,7-dihydropyrazolo(1,5-a)pyrimidines”; XP002252692 retrieved from STN Database Accession No. 111:97170 abstract & Khimiya Geterotsiklicheskikh Soedinenii, 7: 962-965 (1988).

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