Pyrazolo[1,5-a]pyrimidine derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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C514S259300

Reexamination Certificate

active

07667036

ABSTRACT:
The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent MAPKAP-K2 inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for MAPKAP-K2 mediated disorder, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.

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Shiota et. al. (Chem. and Pharm. Bull., 1999, 47(7), 928-938).
Machine Translation of JP 11-279178, downloaded Mar. 25, 2008.
CAS online structure search downloaded Mar. 24, 2008.
Miller et. al. (Advances in Cyclic Nucleotide and Proteins Phosphorylation Research, 1984, 16, 277-290).
D. Williamson et al. “Structure-guided design in pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2” Bioorganic & Medicinal Chemistry Letters, vol. 15, No. 4, pp. 863-867, 2005.
Paruch et al., “Pyrazolo[1,5-α]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2”, Biorganic & Medicinal Chemistry Letters, 17:6220-6223 (2007).

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